僅用于工業(yè)應(yīng)用或科學研究,不可用于人類或動物的臨床診斷或治療,非藥用.Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.Adezapimod(SB203580,RWJ 64809,PB 203580)是一種p38 MAPK抑制劑,在THP-1細胞中的IC50為0.3-0.5μM,對SAPK3(106T)和SAPK4(106T)的敏感性降低10倍,并以3-5μM的IC50阻斷PKB磷酸化,SB203580誘導線粒體自噬和自噬